Efficacy of Turmeric and Black seeds (Kalonji) in metabolic syndrome: A clinical study
by Forest Raga January 16, 2021
The present study was carried out to investigate the efficacy and safety of Turmeric and Black seeds (Kalonji) in metabolic syndromeAims & objectives
To compare the clinical efficacy of Black seeds and Turmeric alone and its co-administration in lower doses among patients with metabolic syndrome (MetS).
Apparently healthy males (n = 250), who screened positive for MetS, were randomized to either Black seeds (1.5 g/day), Turmeric (2.4 g/day), its combination (900 mg Black seeds and 1.5 g Turmeric/day), or placebo for 8 weeks. Main outcome measures: body-mass-index (BMI), body-fat-percent (BF%), waist circumference (WC), hip-circumference (HC), blood pressure (BP), lipid profile (cholesterol, HDL-cholesterol, LDL-cholesterol, and TG), fasting blood glucose (FBG), and c-reactive protein (CRP).
At 4 weeks, compared to baseline, Black seed and Turmeric alone showed improvement in BMI, WC, and BF%. Combination improved all parameters except HDL-cholesterol with lower FBG and LDL-cholesterol as compared to placebo. At 8 weeks, compared to placebo, Black seeds reduced lipids and FBG, while Turmeric reduced LDL-cholesterol and CRP. Interestingly, the combination group with a 60% dose of the individual herbs showed an improvement in all parameters from baseline. When compared to placebo, it reduced BF%, FBG, cholesterol, TG, LDL-cholesterol, CRP, and raised HDL-cholesterol.
Turmeric and Black seeds showed improvement in all parameters of metabolic syndrome when co-administered at 60% of doses of individual herbs with enhanced efficacy and negligible adverse-effects. The combination of Black seeds and Turmeric can, therefore, be recommended with lifestyle modification as a starting point for patients with MetS to halt its future complications and progression.
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