The present study was carried out to investigate the efficacy and safety of the Effects of Chlorophytum borivilianum (Krishna Musli root) on physical performance
OBJECTIVES: The objective was to study the adaptogenic effect of Chlorophytum borivilianum(CB) on physical performance when exposed to accustomed activity (AA) and unaccustomed activity (UA) and the effect of CB on heart rate (HR) and blood pressure (BP) in the presence of UA and the effect on muscle strength in comparison with placebo.
Volunteers were informed about the study by word of mouth, and those who were coming to the institute on a daily basis were recruited in the study. Volunteers who fulfilled the eligibility criteria (male/female between the age groups of 18 and 45 years, normal hematological and biochemical investigations, and not performing any strenuous activity) were included in the study. Those with a history of allergy or intolerance to study drug, addiction, lower- or upper-limb injury, and already taking other Rasayana herbs, pregnant/lactating women, and those with other serious disorder or if volunteers did walk continuously >1 has a part of exercise regimen were excluded from the study.
The standardized powder form of the root of CB was used. Maize starch powder was used as a placebo. The dose of the study drug and placebo was 3 g/day. The dose of the drug was selected from standard ayurvedic textbooks. Both study drugs and placebo were given in a capsule form orally. Each capsule containing 500 mg of the drug was given as two capsules three times a day (TDS) after a meal for 60 days.
Since the study was double-blind (the outcome assessor and volunteers were blinded), capsules of both study drug and placebo were of the same size and color (dark orange), and these drugs were dispensed by the investigator who generated the randomization codes.
After screening, they were randomized using online software into two groups, i.e., 30 in CB and 30 in the placebo group. Randomization was done after a successful screening procedure on the baseline visit (day 0). Randomization codes were generated by the investigator who was not assessing the outcomes.
The evaluation was done on three visits: baseline visit (day 0), day 30, and day 60.
Study drugs for the first 30 days were given to the volunteers on baseline visit, i.e., day 0, and for the next 30 days, it was given on the next visit on day 30. Compliance was assessed by counting the number of capsules in the container on day 30 and day 60. Compliance of >80% was necessary to continue the study.
All the tests were performed in an air-conditioned room (24°C€“26°C), and during each test, a rest period of 15€“20 min was given to the volunteers for the hemodynamic stabilization.
CB, when administered daily to healthy individuals for a 2-month duration, has shown the significant change in all the variables of physical performance when exposed to AA, i.e., distance in 6MWT has increased from 431.66 ± 38 (day 0) to 468.33 ± 0.43 m on day 60 in comparison to placebo and day 0. In the same test, HR after the test decreased from 85.30 ± 9.31 to 78.30 ± 8.26 on day 60 when compared with day 0 and placebo. SBP was also decreased on day 60 in the CB group when it was compared with the placebo (P < 0.05) [Table 1].
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