by Forest Raga December 29, 2020
The present study was carried out to investigate the efficacy and safety of the Shweta Musali (Chlorophytum borivilianum L.) on semen and testosterone
Objective: To examine the effect of Shweta Musali (Chlorophytum borivilianum L.) on semen and testosterone
Treatment Offered
The study population was made up of apparently healthy and consenting male volunteers between 20 to 40 years of age, registered at the OPD of NIA, Jaipur. The study followed the concept of Vajikarana in Ayurveda, which stated that Vajikarana should be administered on a daily basis (Nitya) to disease-free individuals (Kalya) during a young age (Udagra/Tarunavaya).Thus, the age of the study population was stratified at 20-40 years. A total number of 30 volunteers were registered after taking due consent and were randomly assigned to two groups A and B.
Trial drug
Botanically authenticated dried root tubers of C. borivilianum were sourced from the cultivated fields at Shivagangai Farm of Century Agrotech Limited, Chennai. Water extract of the quality-assured samples was prepared and capsulated in soft-gelatin capsules of 500 mg each. Barley powder was encapsulated in similar capsules as a placebo in the study dose because it had practically no effect on semen and testosterone.
Dose, duration, and administration
The trial drug was given as capsules of 500 mg, twice daily, before food, with normal water, for 12 weeks. The volunteers were dispensed the required quantity of the trial drugs on every third week for better compliance.
Grouping of the volunteers
Registered and screened volunteers were randomly divided into two groups A (trial group) and B (placebo group). The trial drug and the placebo were sealed in plastic containers containing 180 capsules. These containers were coded by a person not related to the study. The coding documents were sealed and kept under safe custody. The envelope was opened after completion of the trial, to decode it for interpretation of the observations.
Results
The values of various laboratory parameters of both Groups A (CB) and B (Placebo) and their statistical analysis revealed the following observations [Table 1]
Table 1
- Statistically highly significant increase in semen volume, sperm count, sperm motility, and percent normal sperm morphology. Semen liquefaction time was observed in Group A in comparison to Group B
- Statistically, significant improvement was observed in serum testosterone in Group A when compared with Group B.
Conclusion
The findings of the study prompt the authors to suggest that, Water extract of Chlorophytum borivilianum improves the quantity and quality of semen in a statistically significant manner in healthy male adults between 20 to 40 years of age, in comparison to the placebo, when used for 12 weeks, in a dose of 500 mg b.i.d. Water extract of Chlorophytum borivilianum does improve the serum testosterone level in a majority of volunteers in a trial dose, in comparison to the placebo, but a statistically significant effect was not observed. No volunteer developed any ADR, confirming its safety for human use. Therefore, the study corroborates the traditional claim that Chlorophytum borivilianum is a Shukraldravya, as it improves the semen and testosterone, the commonly accepted equivalents of Shukradhatu.
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