The Antiasthmatic activity of Moringa oleifera Lam: A clinical study


 

 

The present study was carried out to investigate the efficacy and safety of seed kernels of Moringa oleifera in the treatment of bronchial asthma. 

 Moringa has been used for centuries due to its medicinal properties and health benefits. It also has antifungal, antiviral, antidepressant, and anti-inflammatory properties. Moringa oleifera is a medium-sized tree, found wild in the sub-Himalayan tract. The plant is reported to elicit a good clinical response in children suffering from upper respiratory tract infection and skin infection.

Treatment Offered 

A study was conducted to examine Twenty patients of either sex with mild-to-moderate asthma were given finely powdered dried seed kernels in a dose of 3 g for 3 weeks. The clinical efficacy with respect to symptoms and respiratory functions were assessed using a spirometer prior to and at the end of the treatment.

Results

Baseline characteristics like age, height, weight, pulse rate, blood pressure, etc. of patients are shown in Table 1. The habit of smoking was found to be prevalent to the extent of 86% among asthmatic male patients. Also, 25% of patients were found to have a family history of asthma.

Table 1

Baseline characteristics of patients enrolled for the pulmonary function test (PFT) of Moringa oleifera

Variables Mean ± SEM Range
Age (years) 33.4 ± 3.48 17-70
Male/Female 14/06 -
Height (inches) 63.64 ± 0.66 58-70
Weight (kg) 51.96 ± 1.32 38-64
Heart rate (beats/min) 75.72 ± 1.77 56-90
Asthma, duration (year) 5.26 ± 1.35 1-20
Systolic BP (mm Hg) 110.2 ± 2.58 95-150
Diastolic BP (mm Hg) 74.2 ± 2.56 60-110
 
 The hematological parameters were not changed markedly by treatment with M. oleifera. However, the majority of patients showed a significant increase in Hb values, and ESR was significantly reduced in Table 2.

Table 2

Effect of Moringa oleifera on hematological profile of patients

Variables Baseline values After treatment
 

  Mean ± SEM Range Mean ± SEM Range
Hb (g %) 11.54 ± 0.18 10-13.5 11.90 ± 0.18* 10-13.5
TC (per c mm) 7584 ± 226.54 5400-10400 6968 ± 196.28 5400-9800
Neutrophil (%) 71.44 ± 5.0 60-81 67.8 ± 1.0 60-77
Lym. (%) 26.68 ± 1.07 16-38 23.04 ± 1.00 12-34
Eosi. (%) 1.8 0 ± 0.14 1-3 1.28 ± 0.09 0-2
Mono. (%) 1.44 ± 0.14 0-2 1.24 ± 0.08 0-2
ESR (mm/h) 17.4 ± 2.28 5 - 40 11.00 ± 1.47* 5-35
 

Spirometry tests before and after 3 weeks of treatment with M. oleifera revealed a significant increase in FVC and FEV1. Mean % increases in FVC and FEV1 were 32.97 ± 6.03% and 30.05 ± 8.12%, respectively Table 3.

Table 3

Effect of Moringa oleifera on lung functionn

Parameters Before treatment (Mean ± SEM) After treatment (Mean ± SEM) % Increase (Mean ± SEM)
FVC (l) 1.942 ± 0.241 2.365 ± 0.220*** 32.97 ± 6.03
FEV1 (l) 1.592 ± 0.251 1.896 ± 0.246** 30.05 ± 8.12
FEV1/FVC (%) 70.546 ± 6.083 73.656 ± 5.531 6.112 ± 2.555
PEFR (l/s) 3.982 ± 0.541 4.758 ± 0.516*** 32.09 ± 11.75
FEF25-75% (l/s) 2.143 ± 0.57 2.22 ± 0.489 20.04 ± 10.64
MVV (l/min) 34.04 ± 2.76 46.97 ± 5.49** 34.95 ± 8.44

 

Improvement was also observed in % predicted values. Twenty-five percent of patients were having predicted values of FVC above 80% before treatment with M. oleifera. After treatment with M. oleifera, 40% of patients were found to have predicted values of FVC above 80%  Table 4

*Forced vital capacity (FVC) is the amount of air that can be forcibly exhaled from your lungs after taking the deepest breath possible.

Higher the FVC the better. 

Table 4

Effect of Moringa oleifera on % predicted values

% Predicted values Forced vital capacity (% of patients) Forced expiratory volume in one second (% of patients) Peak expiratory flow rate (% of patients)
 


  Baseline M. oleifera Baseline M. oleifera Baseline M. oleifera
20-40 10 10 15 10 40 20
40-60 35 20 35 25 25 30
60-80 30 30 20 25 20 10
80-100 25 40 30 40 15 40

 

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